Why will dogs die if they eat chocolate? I believe that many of my friends have heard that dogs can not eat chocolate, eat it will die, how is this? The following small beans for you to introduce why dogs can not eat chocolate!

Why would a dog die from eating chocolate?

Chocolate is made from cocoa beans and contains many derivatives of methylxanthine, which are caffeine and theobromine. Theobromine is found in chocolate, and it acts on the central nervous system and heart muscle of puppies to poison them. Humans and cats are able to metabolize theobromine, but dogs do not have the digestive system to do so.

Competitive inhibition of cellular adenosine receptors

Intracellular Ca levels =  Strength/contractility of skeletal and cardiac muscle

Competition for benzodiazepine receptors in the central nervous system and inhibition of phosphodiesterase =  cAMP

On the circulation of epinephrine and norepinephrine

[Different chocolate-methylxanthine concentrations]

Dry cocoa powder ~800 mg/oz (28.5 mg/g)

Unsweetened chocolate 450 mg/oz (16 mg/g)

Semi-Sugar Chocolate, Sweet Dark Chocolate ~ 150-160 mg/oz (5.4-5.7 mg/g)

Milk chocolate ~ 64 mg/oz (2.3 mg/g)

Cocoa bean shells ~255 mg/oz (9.1 mg/g)

[Intoxicating dose of methylxanthine]

Mild toxicity seen at ~20 mg/kg

Moderate to severe toxicity seen above 40 mg/kg

Cardiotoxicity seen at ~50 mg/kg

Convulsions seen above 60 mg/kg

Any measurement greater than 40-45 mg/kg should be considered potentially life threatening.

LD50 (theobromine and caffeine) = 100-200 (mg/kg) but individual differences exist. Even consumption of chocolate below the LD50 may cause death in animals.

Calculations:

Taking a 5 kg (10 pounds) dog, eating this 14g bar of milk chocolate would result in an intake of 2.3 x 14 = 32.2mg, which means it is 6.4mg/kg, far from the slightly toxic dose of 20mg/kg, and therefore would not be toxic. This makes it clear that a 2-pound dog would be mildly poisoned if he ate this chocolate, a 3-pound dog is near the threshold, 21.5mg/kg could potentially show symptoms of poisoning, but a 4-pound dog at 16.1 mg/kg would be safe.

WARNING: The above is a scientific calculation and different chocolates contain different amounts of cocoa-like substances, so do not attempt to do this experiment with your own dog. Please take to the hospital immediately in case of obvious symptoms of poisoning.

[Symptoms of poisoning]

CNS excitation

Tremors

Excitement

Seizures

Cardiac stimulation. Cardiac stimulation

Dysrhythmias Cardiac Rhythm Abnormalities

Hypertension

Vomiting and vomiting